Voiceprints Detect Early Alzheimer's; Leucovorin Guidance Issued; CTE and DNA Damage
Neurology > General Neurology
— News and commentary from the world of neurology and neuroscience
November 4, 2025 • 1 min read
Voiceprints Uncover Early Alzheimer's
A groundbreaking study published in npj Dementia reveals a novel method for early detection of Alzheimer's and related dementias. Researchers utilized digital voice recordings to identify subtle changes in speech patterns, enabling the detection of the disease at its earliest stages. This non-invasive approach could revolutionize diagnosis and potentially lead to more effective treatment strategies.
Vamorolone Shows Promise in Duchenne Muscular Dystrophy
Santhera Pharmaceuticals announced positive five-year data for vamorolone (Agamree), indicating improved safety and comparable effectiveness to corticosteroids in managing Duchenne muscular dystrophy. This breakthrough could significantly enhance the quality of life for individuals with this debilitating condition.
Leucovorin Use in Autism: A Cautionary Note
The American Academy of Pediatrics advises against the routine use of leucovorin (folinic acid) for autistic children at this time. This decision highlights the ongoing research and need for personalized treatment approaches in autism spectrum disorders.
Central Nervous System Cancer Incidence: A Stabilizing Trend
A study published in JAMA Neurology reveals that the incidence rate of central nervous system cancers in the U.S. remained stable from 1990 to 2021. However, disability-adjusted life-years and mortality rates showed a positive decline, suggesting advancements in cancer management and treatment.
Gamification Boosts Parkinson's Patients' Activity
A small clinical trial published in JAMA Neurology demonstrates the effectiveness of gamification interventions in increasing daily steps among military veterans with Parkinson's disease. This innovative approach could improve physical activity and overall well-being for individuals with this neurodegenerative disorder.
BrainSTEM Atlas: Mapping the Developing Brain
The open-source BrainSTEM atlas, introduced in Science Advances, has mapped every cell of the developing human brain. This comprehensive resource may significantly contribute to Parkinson's research and our understanding of brain development.
CTE and DNA Damage: A Troubling Connection
Brain samples analyzed in Science reveal a link between chronic traumatic encephalopathy (CTE) and DNA damage, similar to that observed in Alzheimer's disease. This finding suggests that the same genetic changes may contribute to neurodegeneration in both conditions, opening new avenues for research and treatment.
FDA Feedback on AMT-130: A Setback for Huntington's Research
uniQure announced that the FDA's feedback on phase I/II data of investigational AMT-130 in Huntington's disease may hinder the progress of a biologics license application. This development underscores the challenges in translating research into clinical practice and the need for continued innovation in drug development.
Cortical Glutamatergic and GABAergic Inputs: Stabilizing Memory Formation
A mouse study published in Science suggests that cortical glutamatergic and GABAergic inputs play a crucial role in stabilizing memory formation. This discovery could lead to new therapeutic targets for memory-related disorders.
